The biochemical basis of tolerance to malathion in Rhodnius prolixus

Add time:08/15/2019    Source:sciencedirect.com

1. lc50 of malathion, fenitrothion and lindane were determined in R. prolixus and T. infestons. R. prolixus was shown to be tolerant to malathion.2. The penetration rate of (14C)-malathion into R. prolixus and T. infestans was similar.3. Acetylcholinesterase from R. prolixus heads was 3.3-fold less sensitive to inhibition by malaoxon than the similar enzyme of T. infestans.4. R. prolixus showed more activity of GSH-S-transferases against DCNB than T. infestons.5. The in vitro degradation of (14C)-malathion demonstrated that R. prolixus is more active than T. infestans in carboxyester splitting to give α and β monoacids.6. The synergism of TPP and TOCP on malathion toxicity was higher in R. prolixus than in T. infestans.7. Esterase activity against a and β naphthyl acetates proved to be much lower in R. prolixus homogenates than in T. infestans homogenates. An inverse result was observed when PTA was the substrate.

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