Enantioselective [2,3] wittig ring contraction induced by chiral bases. The total synthesis and absolute configuration of (+)-Aristolactone (cas 6790-85-8)

Add time:07/13/2019    Source:sciencedirect.com

[2,3] Wittig ring contraction of the achiral 13-membered acetylenic ether 1 via treatment with lithio (R,R) or (S,S)-bis-(1-phenylethyl)amide afforded the (R)-(+) or (S)-(-)-propargylic alcohol (+)-2 or (-)-2, respectively, of > 60% ee in 75% yield.

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