Determination of DIOXOPROMETHAZINE HYDROCHLORIDE (cas 15374-15-9) by capillary electrophoresis with electrochemiluminescence detection

Add time:08/07/2019    Source:sciencedirect.com

The paper presents a rapid method for the determination of DIOXOPROMETHAZINE HYDROCHLORIDE (cas 15374-15-9) (DPZ), an antihistamine drug, by the capillary electrophoresis with electrochemiluminescene detection (CE–ECL) using tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy)32+) reagent. This CE–ECL detection method has high sensitivity, good selectivity and reproducibility for DPZ analysis. Under the optimized conditions: separation capillary, 38 cm length (25 μm i.d.); sample injection, 10 s at 8 kV; separation voltage, 12.5 kV; running buffer, 20 mmol L−1 sodium phosphate of pH 6.0; detection potential, 1.15 V; 50 mmol L−1 of phosphate buffer (pH 7.14) containing 5 mmol L−1 of Ru(bpy)32+ in ECL detection cell, the detection limit of DPZ was 0.05 μmol L−1 (S/N = 3). The linear range extended from 5 to 100 μmol L−1. The linear curve obtained was Y = 181.62 + 9.28X with a correlation coefficient of 0.9970. The relative standard deviations of the ECL intensity and the migration time for six continuous injections of 5 μmol L−1 DPZ were 3.7% and 0.92%, respectively. The CE–ECL method was applied to analyze DPZ in real samples including tablets, rat serum and human urine, and satisfactory results were obtained without interference from samples matrix. The CE–ECL technique was proved to be a potential method for the detection of DPZ in clinic analysis.

We also recommend Trading Suppliers and Manufacturers of DIOXOPROMETHAZINE HYDROCHLORIDE (cas 15374-15-9). Pls Click Website Link as below: cas 15374-15-9 suppliers

Prev:Dipeptides containing the α-aminoisobutyric residue (Aib) as ligands: preparation, spectroscopic studies and crystal structures of copper(II) complexes with H-Aib-X-OH (X=Gly, l
Next:New aspects of the electroreduction of palladium dichloride complex with 1,2-bis(diphenylphosphino)ethane)