Synthesis of vinyl and electron-deficient aryl trifluoromethyl sulfides via Csp2−OH bond activation with AgSCF3 and n-Bu4NI/KI

Add time:08/07/2019    Source:sciencedirect.com

Direct dehydroxytrifluoromethylthiolation of enols and electron-deficient phenols with AgSCF3 in the presence of n-Bu4NI and KI is reported, affording a series of vinyl and aryl trifluoromethyl sulfides in moderate to excellent yields. This work represents a rare example of direct functionalization of Csp2−OH bonds.

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