Isolation and structure determination of (+)-trienomycin F. An endgame synthetic strategy for the trienomycin family of antitumor antibiotics

Add time:08/09/2019    Source:sciencedirect.com

A new trienomycin antibiotic, (+)-trienomycin F (4), has been isolated and characterized. The structure was elucidated via spectroscopic comparison with semisynthetic 4 prepared from (+)-trienomycinol (5). The latter sequence implemented an endgame synthetic strategy designed to furnish the trienomycin family of antibiotics from a common advanced intermediate [i.e., macrocycle (+)-5].

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