Systematic synthesis of specifically 13C/2H - labeled nucleosides from [ul-13C6]-d

Add time:08/10/2019    Source:sciencedirect.com

A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucose. We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose. Selectively 13C/2H - doubly labeled nucleosides, such as [1′,2′,3′,4′,5′-13C5;3′,5′-2H2]- and [1′,2′,3′,4′,5′-13C5;4′,5′-2H2]-adenosines, have been synthesized starting from [ul-13C6]-d-glucose. These labeled nucleosides are very useful for precise conformational analyses of nucleic acids in solution by heteronuclear multidimensional NMR spectroscopy.

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