Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats

Add time:08/09/2019    Source:sciencedirect.com

Background and aimCrohn's disease is a relapsing inflammatory condition afflicting the digestive tract. Drugs used for treatment of Crohn's disease may be associated with serious side effects. Endogenous opioid peptides modulate inflammatory cytokine production. Opioid antagonists have been shown to play a role in healing and repair of tissues. This work was designed to detect the possible beneficial effects of opioid antagonist naltrexone in indomethacin-induced Crohn's disease in rats.

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