Nicotinium methane sulfonate (NMS): A bio-renewable protic ionic liquid and bi-functional catalyst for synthesis of 2-amino-3-cyano pyridines

Add time:08/09/2019    Source:sciencedirect.com

In this work, a simple approach was used to quantitative preparation of nicotinum methane sulfonate (1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium methanesulfonate (NMS)) from nicotine and methane sulfonic acid. NMS, as a novel, mild, efficient, economic, and task-specific ionic liquid (TSIL) with dual acid and base functional groups, has been characterized by NMR, FT-IR, acidity measurements, and elemental analysis. This protic ionic liquid shows excellent catalytic activity in one-pot synthesis of 2-amino-3-cyanopyridines in 78–98% from malononitrile, aromatic aldehydes, methyl ketones, and ammonium acetate under solvent-free conditions. NMS is a nature-based recyclable and reusable catalyst.

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