Selected biological activities of novel selenonium choline (cas 135001-09-1) analogs

Add time:08/09/2019    Source:sciencedirect.com

1.1. The novel choline analogs selenonium choline (cas 135001-09-1) (SeCh) and acetylselenonium choline (ASeCh) have been examined for selected biological activities.2.2. ASeCh was found to be an alternative substrate for acetylcholin esterase with Km and Vmax values similar to acetylcholine.3.3. ASeCh and SeCh inhibited acetylthiocholine hydrolysis by acetylcholinesterase with IC50 values similar to acetylcholine and choline.4.4. SeCh exerted a protective action against physostigmine and DFP induced toxicity.5.5. SeCh (85 mg/kg) was found to be 3 times more toxic in mice than choline.

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