Accelerated communication muscarinic and nicotinic activities of the novel acetylcholine analog acetylselenonium choline (cas 135001-09-1)

Add time:08/12/2019    Source:sciencedirect.com

The present paper further characterizes the cholinergic properties of acetylselenonium choline (ASeCh, (CH3)2Se+CH2CH2OCOCH3). The data demonstrate that ASeCh possesses muscarinic receptor agonist properties as evidenced by vasodepressor and smooth muscle contractile activities which are enhanced by physostigmine and antagonized by atropine. ASeCh also possessed nicotinic agonist activity on frog rectus abdominis tissue which was potentiated by physostigmine, and blocked by d-tubocurarine. The relative potencies of ASeCh ranged from ∼1 % to ∼6 % of the potency of acetylcholine in the three types of preparations examined.

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