Radioprotective effect of low doses of 2-(1-naphthylmethyl)-2-imidazoline alone or associated with phosphorothioates
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Add time:08/11/2019 Source:sciencedirect.com
In the mouse, the intraperitoneal injection of 2-(1-naphthylmethyl)-2-imidazoline has a radioprotective effect even at low low doses. Its association with S-[2-(3-aminopropyl)aminoethyl] phosphorothioate (WR 2721) or S-[3-(3-methylaminopropyl)-amino-propyl]phosphorothioate (WR 151327) at low doses led to an enhancement of their respective radioprotective activities without any apparent side effects. These results strengthen the interest of this non-sulphur compound as a radioprotector.
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