Preparation and biological evaluation of 3-[76Br]bromo-α-methyl-l

Add time:08/10/2019    Source:sciencedirect.com

Introduction3-[18F]fluoro-α-methyl-l-tyrosine ([18F]FAMT) is a useful amino acid tracer for positron emission tomography (PET) imaging of malignant tumors. FAMT analogs labeled with 76Br, a positron emitter with a long half-life (t1/2=16.1 h), could potentially be widely used as amino acid tracers for tumor imaging. In this study, 3-[76Br]bromo-α-methyl-l-tyrosine ([76Br]BAMT) was designed, and its usefulness was evaluated as a novel PET tracer for imaging malignant tumors.

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