Administration of Colistin sulfate (cas 1264-72-8) in endotoxic model at slow and sustained fashion may reverse shock without causing nephrotoxicity in its optimal concentration

Add time:08/12/2019    Source:sciencedirect.com

ObjectivesDespite of proven LPS neutralizing activity, intravenous polymyxin use was waned due to experience of associated nephrotoxicity. But, increasing resistance to all available antibiotics has necessitated their resurgence and the prodrug of Colistin sulfate (cas 1264-72-8) (CS), known as colistin-methanesulfonate (CMS), is increasingly used as the only therapeutic option in many infections. Currently available CMS employ very different dose definitions and thus because of complex pharmacokinetics/pharmacodynamics information and short half-life, this drug use remains confusing. We aimed to expose CS in endotoxic shock models by micro-osmotic pump and evaluated its effectiveness.

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