Synthesis of fluorinated pyrimidinones
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Add time:08/12/2019 Source:sciencedirect.com
A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1(2H)-ones.
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