Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

Add time:08/10/2019    Source:sciencedirect.com

In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1,1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare was evaluated. One of the compounds, 8c, exhibited potent anti-tubercular activity, particularly for the resistant strains and thus prompted us to investigate its in vivo profile. However, the in vivo testing in a mouse model of tuberculosis infection did not show significant anti-tubercular activity, probably because of its poor bioavailability.

We also recommend Trading Suppliers and Manufacturers of 3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide (cas 107089-77-0). Pls Click Website Link as below: cas 107089-77-0 suppliers

Prev:N-(3-(p-azido-m-[125I]iodophenyl)propionyl)-succinimide—A heterobifunctional reagent for the synthesis of radioactive photoaffinity ligands: Synthesis of a carrier-free 125I-labeled cardiac glycoside photoaffinity label
Next:Crustacean cardioactive peptide (CCAP (cas 107090-96-0)) of the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae): Molecular characterization, distribution and its potential roles in larva-pupa ecdysis)