Design of silicon-based misonidazole (cas 13551-87-6) analogues and 18F-radiolabelling

Add time:08/10/2019    Source:sciencedirect.com

IntroductionDevelopment of new 18F-labeled tracers for positron emission tomography (PET) imaging is increasingly important. Herein, we described the synthesis of silicon analogues of [18F]fluoromisonidazole (cas 13551-87-6) in order to develop new radiolabelled compounds for the detection of tumour hypoxic domain. Their stabilities and their in vivo biodistribution were evaluated.

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