Detection of a reactive metabolite of misonidazole (cas 13551-87-6) in human urine
-
Add time:08/11/2019 Source:sciencedirect.com
Chemical studies have indicated that, following reduction of misonidazole (cas 13551-87-6) to the hydroxylamine derivative, reaction with guanosine leads to the formation of a 2-carbon addition product of guanosine. In this study, the formation of the guanosine product is used to detect the presence of a reactive metabolite of misonidazole in the urine of patients treated with misonidazole. Urine samples were incubated with [14C]guanosine and the guanosine product was separated by HPLC analysis. The quantities of product vary as much as 10-fold from patient to patient and it is suggested that the assay might be useful as a predictor of patients susceptible to the development of peripheral neuropathy or other effects of misonidazole.
We also recommend Trading Suppliers and Manufacturers of misonidazole (cas 13551-87-6). Pls Click Website Link as below: cas 13551-87-6 suppliers
Prev:Design of silicon-based misonidazole (cas 13551-87-6) analogues and 18F-radiolabelling
Next:Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information