Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles
-
Add time:07/12/2019 Source:sciencedirect.com
Series of flavones and methyl-4H-1-benzopyran-4-ones carrying mono or diamidinobenzimidazoles at different positions were synthesized and evaluated for antibacterial and antifungal activities against E. coli, S. aureus, MRSA (methicillin-resistant S. aureus), MRSE (methicillin-resistant S. epidermidis), S. faecalis and C. albicans, C. krusei. The results showed that while all diamidines are inactive, the compounds having monoamidinobenzimidazoles at the C-6 position of the 2-phenyl-4H-1-benzopyran-4-one have potent antibacterial activities, particularly, against Gram-positive bacteria. Compounds 23 and 22 exhibited the best inhibitory activity with MIC values of 1.56 μg/mL against S. aureus, MRSA, MRSE and 3.12 μg/mL against C. albicans, respectively.
We also recommend Trading Suppliers and Manufacturers of 4H-1-Benzopyran-4-one, 7-Methyl- (cas 5751-51-9). Pls Click Website Link as below: cas 5751-51-9 suppliers
Prev:Inactivation of bovine plasma amine oxidase by 1,1,1–trihalo–3–aminopropanes
Next:Synthesis, mesomorphic properties and X-ray diffraction studies on 7-alkyloxy-3-(4-alkyloxyphenyl-4H-1-benzopyran-4-one: Crystal structure of 7-hexyloxy-3-(4-hexyloxyphenyl)-4H-1-benzopyran-4-one) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Preparative routes to spiroacetals derived from chroman-4-one (2,3-dihydro-4H-1-benzopyran-4-one)07/21/2019
- Some novel aspects of regioselectivity in 1,3 dipolar cycloadditions of 4h-1-benzopyran-4-thione07/19/2019
- Production and toxicity of 2,3-dihydro-5-hydroxy-2-methyl-4H-1-benzopyran-4-one by Phialophora gregata07/18/2019
- A study of claisen rearrangements of (1,1-dimethyl-3-prop-2-prop-2-ynyloxy)-[4H]-1-benzopyran-4-one derivatives.07/17/2019
- Synthesis and antiaggregator activity of some new derivatives of 4H-1-benzopyran-4-one07/16/2019
- Synthesis and structural study on heterocyclic compounds 7-decanoyloxy-3-(4′-substitutedphenyl)-4H-1-benzopyran-4-ones: Crystal structure of 7-decanoyloxy-3-(4′-methylphenyl)-4H-1-benzopyran-4-one07/15/2019
- 2-(Dialkylamino)-4H-1-benzopyran-4-one derivatives modify chloride conductance in CFTR expressing cells07/14/2019
- Synthesis, mesomorphic properties and X-ray diffraction studies on 7-alkyloxy-3-(4-alkyloxyphenyl-4H-1-benzopyran-4-one: Crystal structure of 7-hexyloxy-3-(4-hexyloxyphenyl)-4H-1-benzopyran-4-one07/13/2019
