Synthesis and antiaggregator activity of some new derivatives of 4H-1-benzopyran-4-one

Add time:07/16/2019    Source:sciencedirect.com

SummaryA series of 2-[2-alkyl-1H-benzimidazol-5(6)-yl]-4H-1-benzopyran-4-one analogues 7a-7e was synthesized by the reaction with 3′,4′-diaminoflavone and aliphatic carboxylic acids. 3′,4′-Diaminoflavone 6 was prepared via the reduction of 2-(4-amino-3-nitrophenyl)-4H-1-benzopyran-4-one 5a. The compounds 7a-e and 14a-f were tested in vitro for their inhibitory activities against human platelet aggregation induced by collagen, ADP and A23187. The compound with a COOR group as a side chain, 2-(2-alkyloxycarbonyl-2,3-dihydro-l,4-benzodioxin-6-yl)-4H-1-benzopyran-4-one 14a-f, has potent activity, and so compound 13 was also prepared as an analogue of series 14 and tested for its antiaggregator activity.

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