Effect of 2-(4-benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol on blood glucose concentration

Add time:08/11/2019    Source:sciencedirect.com

In finding that 2-(4-benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol (BPHPP) produced high concentrations of blood glucose in rats, it was observed that (1) the maximum concentration of blood glucose was obtained 1 hr after oral administration at a dose of 100 mg/kg of BPHPP, (2) that BPHPP has no effect on the secretion of adrenal corticosterone, (3) that BPHPP markedly inhibited cAMP phosphodiesterase activity, in vitro, and (4) that in the preliminary experiment, the hepatic cAMP levels increased 1.7-fold by the administration (10 mg/kg) of BPHPP.From these results, it was presumed that the high concentrations of blood glucose may be the results of elevations in the intracellular cAMP levels due to the inhibitory action of BPHPP on cAMP phosphodiesterase.

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