Stabilization of egg phosphatidylcholine liposomes by the insertion of sulfatide

Add time:08/16/2019    Source:sciencedirect.com

The characteristic effects of sulfatide and its derivatives on the stability of small unilamellar vesicles of egg phosphatidylcholine liposomes in phosphate-buffered saline were investigated by measuring the leakage of carboxyfluorescein that had been entrapped in these vesicles. We found that both the sulfate group and a long acyl chain, such as lignoceric acid, of the sulfatide are essential for the stabilization. The sulfatide derivatives that contain a somewhat shorter acyl chain such as stearic acid had no effect to suppress the leakage of carboxyfluorescein. The galactose residue of sulfatide is not essential to suppress the leakage. 1H-NMR study using a paramagnetic shift reagent demonstrated that the distribution of phosphatidylcholine in the vesicles containing sulfatide is homogeneous, which seems to contribute to the stability of the membrane.

We also recommend Trading Suppliers and Manufacturers of SULFATIDE SODIUM SALT (cas 113255-27-9). Pls Click Website Link as below: cas 113255-27-9 suppliers

Prev:Studies on scavenger receptor inhibitors. Part 1: synthesis and structure–activity relationships of novel derivatives of sulfatides
Next:Sulfatide-binding proteins)