Synthesis, and In vitro and In vivo muscarinic pharmacological properties of a series of 1,6-Dihydro-5-(4H)-pyrimidinone oximes

Add time:08/12/2019    Source:sciencedirect.com

A series of 1,6-dihydro-5-(4H)-pyrimidinone oxime derivatives I was synthesized (Scheme. 1Download high-res image (53KB)Download full-size imageScheme. 1. Synthesis of dihydropyrimidine oxime derivatives. (A) O=C(CH2NH2)2, MeOH, 20–96 h reflux; (B) O=(CH2Cl2)2, MeOH, 2 h, 40 °C; (C) PhtNK, DMF, 4 h, 100 °C; (D) NaONH2, MeOH, 2 h, rt; (E) HC(OCH3)3, MeOH, 20 h, reflux; (F) CH3C(OCH3)3, MeOH, 20 h reflux; (G) H2NH2C(C=O)CH(CH3)NH2MeOH, 20 h reflux.

We also recommend Trading Suppliers and Manufacturers of 5-PyriMidinaMine, N-(phenylMethyl)- (cas 104479-78-9). Pls Click Website Link as below: cas 104479-78-9 suppliers

Prev:Electronic and optical features of N,N′-bis(4-aminophenyl)1,4-quinonenediimine doped with silicotungsten polyacid: Experimental and numerical studies
Next:Vibrational spectroscopy, intramolecular CH⋯O interaction and conformational analysis of 2,5-dimethyl-benzyl benzoate)