Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases

Add time:08/17/2019    Source:sciencedirect.com

Cathepsins are an important category of enzymes that have attracted great attention for the delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug delivery systems. These proteases can be utilized for instance through actuation of polymer-drug conjugates (e.g., triggering the drug release) to bypass limitations of many drug candidates. A substantial amount of work has been witnessed in the design and the evaluation of Cathepsin-sensitive drug delivery systems, especially based on the tetra-peptide sequence (Gly-Phe-Leu-Gly, GFLG) which has been extensively used as a spacer that can be cleaved in the presence of Cathepsin B. This Review Article will give an in-depth overview of the design and the biological evaluation of Cathepsin-sensitive drug delivery systems and their application in different pathologies including cancer before discussing Cathepsin B-cleavable prodrugs under clinical trials.

We also recommend Trading Suppliers and Manufacturers of CATHEPSIN G FROM HUMAN LEUKOCYTES (cas 107200-92-0). Pls Click Website Link as below: cas 107200-92-0 suppliers

Prev:Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D
Next:PaperThe degradation of bovine and human prothrombin by human polymorphonuclear leukocyte cathepsin g)