C2-symmetric 1,2-diamine/copper(II) trifluoromethanesulfonate complexes as chiral catalysts. Asymmetric cyclopropanations of styrene with diazo esters

Add time:08/13/2019    Source:sciencedirect.com

Styrene and diazo esters react in the presence of copper(II) trifluoromethanesulfonate (1 mol%) and (1S,2S)-N,N′-di(mesitylmethyl)-1,2-diphenyl-1,2-ethanediamine (2 – 3 mol%) to give 2-phenyl-1-cyclopropanecarboxylates in good to excellent optical yields. This reaction has been applied tov the synthesis of chrythanthemic acid.

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