Oxidative debenzylation of 4-methoxy-α-methylbenzyl esters

Add time:08/14/2019    Source:sciencedirect.com

4-Methoxy-α-methylbenzyl alcohol was introduced as a new protecting group for carboxylic acids. 4-Methoxy-α-methyl benzyl esters obtained from the coupling of 4-methoxy-α-methylbenzyl alcohol and corresponding acids, were hydrolyzed in good yield by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ). This process is compatible with several functional groups which are vulnerable to the reductive debenzylation reaction.

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