Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. A route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids

Add time:08/16/2019    Source:sciencedirect.com

Six-, five-, four- and three-membered 1,1-cycloalkanedicarboxylic acid (2a–d) were synthesized by alkaline hydrolysis of the corresponding diesters (1a–d) and the reactions of the formers with SF4 were investigated. 1,1-Bis(trifluoromethyl)cycloalkanes (3a–d) were the products of the reactions conducted at 120–150°C while at 30°C 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes (4a–d) were exclusively formed. The latter were isolated as pure compounds or converted in situ into 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids (5a–d).

We also recommend Trading Suppliers and Manufacturers of 1,1-BIS(TRIFLUOROMETHYL)-2,2-DICYANOETHYLENE 97 (cas 1113-69-5). Pls Click Website Link as below: cas 1113-69-5 suppliers

Prev:A facile approach to fluorinated tetra-substituted alkenes via bis-Suzuki coupling reaction of 2-trifluoromethyl-1,1-dibromoalkenes
Next:Optically active isoxazolidines and 1,3-amino alcohols by asymmetric selenocyclization reactions of O-allyl oximes)