Optically active isoxazolidines and 1,3-amino alcohols by asymmetric selenocyclization reactions of O-allyl oximes

Add time:08/13/2019    Source:sciencedirect.com

The selenyl triflate generated from the reaction of di-2-[(1S)-1-(methylthio)ethyl]phenyl diselenide with silver triflate reacts with various substituted O-allyl oximes to promote ring closure, which affords optically active isoxazolidines in high yields and with good diastereoselectivity (up to 93:7). Enantiomerically enriched 1,3-amino alcohols can be easily obtained by NO bond cleavage of these heterocycles, which was readily effected by treatment with zinc in aqueous acetic acid.

We also recommend Trading Suppliers and Manufacturers of 2,4-dimethylpentan-3-one oxime (cas 1113-74-2). Pls Click Website Link as below: cas 1113-74-2 suppliers

Prev:Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. A route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids
Next:Solvent extraction of base metals by mixtures of organophosphoric acids and non-chelating oximes)