AnalyticalA dual-monoclonal, sandwich immunoassay specific for glucagon like peptide-19–36/7 (GLP-19–36/7)

Add time:08/13/2019    Source:sciencedirect.com

ObjectiveGlucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L-cells which stimulates glucose-dependent insulin secretion. GLP-1 is initially secreted as the active peptide GLP-17–36/7, but rapidly undergoes cleavage by dipeptidyl peptidase 4 (DPP4) to yield the inactive form, GLP-19–36/7. Despite a reduced affinity for the GLP-1 receptor, GLP-19–36/7 may have cardioprotective properties. There is currently no described immunoassay capable of specifically measuring GLP-19–36/7.

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