Chemical synthesis of 4,4′-dimethyl-7-oxygenated sterols. Inhibitors of 3-hydroxy-3-methylglutaryl reductase

Add time:08/13/2019    Source:sciencedirect.com

The chemical syntheses of 4,4′-dimethylcholest-5-en-3β-ol-7-one, 4,4′-dimethylcholest-5-ene-3β,7β-diol and 4,4′-dimethylcholest-5-ene-3β-7α-diol are described. All of these compounds were found to be potent inhibitors of 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase activity in cultured mouse L cells. The synthetic scheme developed in this study utilizes commercial cholesterol as the starting material and provides a simplified method for the preparation of 4,4′-dimethyl-7-oxygenated steroids.

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