Tebuconazole (cas 107534-96-3) induces triazole-resistance in Aspergillus fumigatus in liquid medium and soil
-
Add time:08/15/2019 Source:sciencedirect.com
Aspergillus fumigatus is the mainly leading cause of invasive aspergillosis associated with significant morbidity and mortality in immunocompromised patients. However, triazole resistance in A. fumigatus has increased dramatically throughout the world nowadays. The emergence of triazole resistance has aroused growing concern. This research was conducted to assess if the resistance in A. fumigatus and its associated mutations in the cpy51A gene could be induced during its exposure to Tebuconazole (cas 107534-96-3) in liquid medium and in soil. The results indicated that the resistance in A. fumigatus with mutations of TR46/Y121F/T289A could be induced by tebuconazole in liquid medium. Nine resistant strains without any mutation in cyp51A were isolated in soil treated with tebuconazole at levels of 0.5–5.0 mg kg−1 after incubation for 120 d. The two (HI-30 and HI-36) of the nine resistant isolates were caused by overexpression of AtrF, AfuMDR1, cyp51A and cyp51B and hereditary stability. This strongly implies that conventional application of tebuconazole for plant protection will cause resistance of A. fumigatus to triazole medicals in agricultural soils.
We also recommend Trading Suppliers and Manufacturers of Tebuconazole (cas 107534-96-3). Pls Click Website Link as below: cas 107534-96-3 suppliers
Prev:Endocrine disrupting effects of Tebuconazole (cas 107534-96-3) on different life stages of zebrafish (Danio rerio)☆
Next:Pubertal exposure to Tebuconazole (cas 107534-96-3) increases testosterone production via inhibiting testicular aromatase activity in rats) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Biodegradation of fungicide Tebuconazole (cas 107534-96-3) by Serratia marcescens strain B1 and its application in bioremediation of contaminated soil08/23/2019
- In vitro enantioselective study of the toxicokinetic effects of chiral fungicide Tebuconazole (cas 107534-96-3) in human liver microsomes08/22/2019
- Chiral bioaccumulation behavior of Tebuconazole (cas 107534-96-3) in the zebrafish (Danio rerio)08/21/2019
- Preparation and characterization of Tebuconazole (cas 107534-96-3) metal-organic framework-based microcapsules with dual-microbicidal activity08/20/2019
- Research articleToxic effects of the fungicide Tebuconazole (cas 107534-96-3) on the root system of fusarium-infected wheat plants08/19/2019
- Insights into the effect on silkworm (Bombyx mori) cocooning and its potential mechanisms following non-lethal dose Tebuconazole (cas 107534-96-3) exposure08/18/2019
- Parental exposure to Tebuconazole (cas 107534-96-3) causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring08/17/2019
- Pubertal exposure to Tebuconazole (cas 107534-96-3) increases testosterone production via inhibiting testicular aromatase activity in rats08/16/2019
- Endocrine disrupting effects of Tebuconazole (cas 107534-96-3) on different life stages of zebrafish (Danio rerio)☆08/14/2019