Pubertal exposure to Tebuconazole (cas 107534-96-3) increases testosterone production via inhibiting testicular aromatase activity in rats

Add time:08/16/2019    Source:sciencedirect.com

Tebuconazole (cas 107534-96-3) is a triazole compound used agriculturally to treat plant pathogenic fungi. However, whether pubertal exposure to tebuconazole affects Leydig cell development remains unknown. Here, we exposed male Sprague-Dawley rats at 35 days of age to 0, 25, 50, or 100 mg kg−1 day−1 tebuconazole for 21 days. Tebuconazole exposure increased serum testosterone level but lowered estradiol level at a dose of 100 mg kg−1, without affecting serum luteinizing hormone and follicle-stimulating hormone concentrations. Tebuconazole up-regulated the expression of testicular Cyp11a1, Hsd11b1, and Fshr genes as well as their proteins at a dose of 100 mg kg−1. However, tebuconazole did not stimulate the proliferation of Leydig cells. Tebuconazole in vitro inhibits aromatase activity in primary rat Leydig cells with IC50 value of 40 μmol/L. In conclusion, tebuconazole exposure stimulates pubertal Leydig cell differentiation via inhibiting aromatase activity.

We also recommend Trading Suppliers and Manufacturers of Tebuconazole (cas 107534-96-3). Pls Click Website Link as below: cas 107534-96-3 suppliers

Prev:Tebuconazole (cas 107534-96-3) induces triazole-resistance in Aspergillus fumigatus in liquid medium and soil
Next:Parental exposure to Tebuconazole (cas 107534-96-3) causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring)