Neurochemical and behavioral effects of N-ethyl-acetylcholine aziridinium chloride in mice

Add time:08/17/2019    Source:sciencedirect.com

N-ethyl-choline aziridinium (ECA) and N-ethyl-acetylcholine aziridinium (EAA) were shown to be inhibitors of high affinity choline uptake in vitro(IC50=0.4 ωMand 1.5 ωM, respectively), and intraventricular administration showed that EAA was more selective in its inhibition of hippocampal choline uptake in vivo. EAA significantly reduced the activity of choline acetyltransferase in the hippocampus 3 to 28 days following intraventricular infusion, but not in the striatum or parahippocampal cortex. Neither muscarinic receptor binding nor glutamic acid decarboxylase activity were affected in any of the three brain regions. EAA (12 or 16 nanomoles, intraventricular) significantly impaired memory performance of mice in a radial arm maze when tested two weeks after treatment. A subgroup analysis implicated long-term reference memory as the mechanism disrupted.

We also recommend Trading Suppliers and Manufacturers of ACETYLCHOLINE-(METHYL-14C) CHLORIDE (cas 16597-28-7). Pls Click Website Link as below: cas 16597-28-7 suppliers

Prev:Original articleDesign and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor
Next:Choline oxidase chemiluminéscent assay, after removal of eserine from medium, of acetylcholine released in vitro from brain slices☆)