Integrating in vitro and in silico approaches to evaluate the “dual functionality” of Palmatine chloride (cas 10605-02-4) in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils

Add time:08/14/2019    Source:sciencedirect.com

BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. Understanding the mechanism of protein aggregation and finding compounds that are capable of inhibiting its aggregation is considered to be highly important for disease therapy.

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