On the mode of action of Edeine (cas 11006-90-9): II. Studies on the binding of Edeine (cas 11006-90-9) to Escherichia coli ribosomes
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Add time:08/21/2019 Source:sciencedirect.com
Edeine (cas 11006-90-9) binds to 70-S ribosomes in the presence of 10 mM MgCl2. At a concentration of Mg2+ of 1 mM the binding is 30 times greater than at 10 mM. Edeine does not affect the formation of polysomes, although some binding of edeine to polysomes is observed. Edeine causes association of 30-S and 50-S subunits to 70-S ribosomes even in the presence of 0.1 mM MgCl2, the concentration which causes dissociation of 70-S ribosomes.
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