POSTER SESSION: NUTRITIONAL SCIENCEInterleukin-1 Alters the Absorption of 51 Chromium

Add time:08/17/2019    Source:sciencedirect.com

Interleukin-1 controls some plasma metals; depresses iron and zinc, increases copper and causes redistribution of these metals in some tissues. When the production and activity of IL-1 persists and escapes regulation, IL-1 itself contributes to pathological processes often seen in the elderly; including the destruction of beta cells of the islet of Langerhans (diabetes), inflammation associated with arthritis and the development of atherosclerotic plaques. IL-1 may alter chromium metabolism. This study evaluated the effects of IL-1 alpha on 51chromium absorption, retention and excretion in male Sprague Dawley rats. Ten animals were fasted for 12 hours, injected intraperotineally with mouse recombinant interleukin-1 alpha (1 μg/kg body weight) or control (0.1% BSA in PBS). Two hours after dosing with die IL-1 alpha, animals were fed 50μl (200 μCi) of 51CrCl3 by micropipette. Blood was collected from the tail at 15, 30 minutes and 1, 2 and 4 hours. Six hours after dosing with 51CrCl3, animals were exsanguinated, blood and tissues were sampled for counting. IL-1 alpha significantly (p< .002) decreased 51Cr in blood, urine and some tissues compared to control. The decreased chromium absorption seen in this study may be due to IL-1-induced inhibition of gastric acid secretion since chromium absorption is to some extent influenced by pH. Furthermore, IL-1 potentiates die synthesis and release of cytoprotective prostaglandins. Previous studies in our lab have found dial antacids prostaglandins and prostaglandin analogues all decrease chromium absorption, whereas aspirin, indomethacin, and ibuprofen, all prostaglandin inhibitors, significantly increase the absorption of chromium. The elderly may be most susceptible to disease-related and drug-induced nutritional deficiencies. Chromium intake in some subsets of the U.S. population is lower than the minimum 50 μg of the estimated safe and adequate (50–200 μg/day). Symptoms associated widi chromium deficiency are aften seen in the elderly and include glucose intolerance, hyperinsulinemia and hypercholesterolemia. The interrelationship between cytokines such as IL-1 and trace minerals such as chromium may be of significance in the pathology and treatment of some diseases.

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