An alternative approach to wound healing field; new composite films from natural polymers for Mupirocin (cas 12650-69-0) dermal delivery

Add time:08/16/2019    Source:sciencedirect.com

In this study, novel adhesive films were prepared for Mupirocin (cas 12650-69-0) dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas in vitro release studies were also performed. In vitro drug release studies demonstrated that mupirocin release was improved. Ex vivo bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.

We also recommend Trading Suppliers and Manufacturers of Mupirocin (cas 12650-69-0). Pls Click Website Link as below: cas 12650-69-0 suppliers

Prev:The effect of Mupirocin (cas 12650-69-0) dressings on postoperative surgical site infections in elective colorectal surgery: A prospective, randomized controlled trial
Next:Bacterial Killing Is Enhanced By Exogenous Administration Of Lysozyme (cas 12650-88-3) In The Lungs)