N-Pyrrolidine-2-ylmethyl)-2-hydroxy-3-aminopinanes as novel organocatalysts for asymmetric conjugate additions of ketones to α-nitroalkenes

Add time:08/16/2019    Source:sciencedirect.com

Novel stereoisomeric natural pinane-derived bifunctional catalysts 3a–d bearing a pyrrolidine unit have been synthesized and examined in the asymmetric conjugate additions of carbonyl compounds to α-nitroalkenes. Six-membered cyclic ketones react with β-nitrostyrene derivatives in the presence of (1R,2R,3R,5R)-2-hydroxy-3-((S)-pyrrolidin-2-ylmethylamino) pinane 3b (10 mol %) with high conversion to afford with diastereoselectivity (dr (syn/anti) up to 97/3), the corresponding Michael adducts with enantiomeric purities of up to 88% ee.

We also recommend Trading Suppliers and Manufacturers of 1-METHOXY-1-METHYLAMINO-2-NITROETHYLENE (cas 110763-36-5). Pls Click Website Link as below: cas 110763-36-5 suppliers

Prev:TheoryBinding from Both Sides: TolR and Full-Length OmpA Bind and Maintain the Local Structure of the E. coli Cell Wall
Next:Separation of 5′-dimethoxytrityl-2′-deoxynucleoside-3′-omethylphosphonamidite diastereomers by normal phase chromatography)