Column and thin-layer chromatographic determination of 5-amino-4-chloro-2-phenyl-3-(2H)-pyridazinone

Add time:08/18/2019    Source:sciencedirect.com

Two methods for the chromatographic separation of technical 5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone (PCA) were developed. These methods also permit the quantitative determination of its isomer (4-amino-5-chloro-2-phenyl-3-(2H)-pyridazinone, iso-PCA) and 4,5-dichloro-2-phenyl-3(2H)-pyridazinone (PCC).The mobile phase for the thin-layer chromatography was chloroform with 1 % methanol, while for the column chromatography benzene with increasing chloroform content was used. In both methods aluminium oxide was used as adsorbent. The isolated compounds were dissolved in methanol and diluted with water. The absorbances were measured at the wavelength of absorption maximum.It was found that PCA has two crystalline modifications and that the compounds described are polarographically active.

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