A two-step synthesis of 2-exo-substituted 2-endo-aminonorbornenes from 2-acetamidonorbornene-2-carboxylic acids

Add time:08/17/2019    Source:sciencedirect.com

2-exo-Substituted 2-endo-acetamidonorbornenes (3) were synthesized in a two-step procedure from 2-acetamidonorbornene-2-carboxylic acids (1, 1′) with exceedingly high exo-selectivities based on a new approach involving anodic decarboxylation followed by organoaluminum-promoted nucleophilic substitution on 2-endo-acetamido-2-exo-methoxynorbornene (2).

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