Original articleComparison of the Effect of Histidine-Rich Glycoprotein and 6-aminohexanoic acid (cas 1319-82-0) on Plasmin Production and Fibrinolysis in Vitro

Add time:08/18/2019    Source:sciencedirect.com

Because histidine-rich glycoprotein binds to the kringle 1-3 domain of plasminogen, it may affect fibrinolysis by reducing fibrin-dependent plasmin production, and in this way it could be mechanistically analogous to 6-aminohexanoic acid (cas 1319-82-0). We tested this hypothesis by comparing the effects of histidine-rich glycoprotein and 6-aminohexanoic acid in an in vitro assay of fibrin-dependent plasmin production mediated by tissue plasminogen activator. Whereas 1 mM of 6-aminohexanoic acid increased the Km of the reaction from ∼0.22 μM to ∼1.7 μM, 2 μM of histidine-rich glycoprotein had no discernible effect. Similar results were obtained in an assay based upon fibrin clot lysis. Therefore, we could not document an effect of histidine-rich glycoprotein on the rate of fibrin-dependent plasmin production.

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