Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-Hydroxypropiophenone (cas 1321-48-8)s
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Add time:08/20/2019 Source:sciencedirect.com
A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.
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