Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-Hydroxypropiophenone (cas 1321-48-8)s

Add time:08/22/2019    Source:sciencedirect.com

The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are important precursors in the synthesis of biologically active chromanones and isoflavanones. A highly chemoselective acetylation of primary hydroxy group in preference to phenolic hydroxy group leading to the formation of enantiomerically enriched monoacetates has been observed.

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