Original Articles11β-Substituted 13β-ethyl gonane derivatives exhibit reversal of antiprogestational activity
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Add time:08/18/2019 Source:sciencedirect.com
The syntheses of three 17α-acetoxy-13β-ethyl-11β-aryl-18,19-dinorpregna-4,9-diene-3,20 diones from levonorgestrel are described. Despite their close structural similarity to the antiprogesterone CDB-2914, one of the compounds exhibits agonistic progestational activity, and the other two compounds are totally inactive.
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