Microbial transformation of maslinic acid by Cunninghamella blakesleana
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Add time:08/20/2019 Source:sciencedirect.com
The pentacyclic triterpenoid maslinic acid (1) was bioconverted by Cunninghamella blakesleana CGMCC 3.910, four metabolites were obtained. On the basis of nuclear magnetic resonance and high-resolution mass spectral analyses, their structures were identified as 2α,3β,7β-trihydroxyolean-12-en-28-oic acid (2), 2α,3β,15α-trihydroxyolean-12-en-28-oic acid (3), 2α,3β,7β,15α-tetrahydroxyolean-12-en-28-oic acid (4), 2α,3β,7β,13β-tetrahydroxyolean-11-en-28-oic acid (5), all of the metabolites were new compounds. The metabolic pathway was also investigated. This was the first report on the biotransformation of maslinic acid.
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