Cardioprotective effects of intracoronary administration of 4-chlorodiazepam in small and large animal models of ischemia-reperfusion

Add time:08/20/2019    Source:sciencedirect.com

BackgroundThe Translocator Protein (TSPO) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. Administration of 4-chlorodiazepam (4-CLD), a TSPO ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. In the present study we investigated a potential cardioprotective effect of intracoronary administration of 4-CLD in small and large animal models of ischemia-reperfusion.

We also recommend Trading Suppliers and Manufacturers of 4'-CHLORODIAZEPAM (cas 14439-61-3). Pls Click Website Link as below: cas 14439-61-3 suppliers

Prev:Research Report4′-Chlorodiazepam is neuroprotective against amyloid-beta through the modulation of survivin and bax protein expression in vitro
Next:Effect of phosphamidon on cognition and oxidative stress and its modulation by ascorbic acid and 4′-chlorodiazepam in rats)