Chiral terpene auxiliaries III: spiroborate esters from (1R,2S,3R,5R)-3-amino-apopinan-2-ol as highly effective catalysts for asymmetric reduction of ketones with borane

Add time:08/17/2019    Source:sciencedirect.com

New spiroborate esters, derived from terpene amino alcohols, (S)-prolinol, and 2-aminoethanol, were employed as catalysts in the borane reduction of acetophenone and other aryl alkyl and halogenated ketones. The corresponding alcohols were obtained in high yields and with enantioselectivities up to 98% ee. The influence of the amino alcohol and the diol moieties of spiroborate on the reaction selectivity was examined. The catalyst load, the nature of the solvent, the borane source, and the reaction conditions were also investigated.

We also recommend Trading Suppliers and Manufacturers of (2S,5R)-Tetrahydrothiophene-2,5-dicarboxylic acid dimethyl ester (cas 19438-91-6). Pls Click Website Link as below: cas 19438-91-6 suppliers

Prev:Effect of hydroxyl ended and end-capped multiarm star polymers on the curing process and mechanical characteristics of epoxy/anhydride thermosets
Next:Synthesis of (S) 2-ethyl-2-methylpentanoic acid from the formate ester of (S) ethyl 2-formyl-3-hydroxy-2-methylpropionate)