Chiral Brønsted acid-catalyzed alkylation of C3-substituted indoles with o-hydroxybenzyl alcohols: highly enantioselective synthesis of diarylindol-2-ylmethanes and evaluation on their cytotoxicity

Add time:08/18/2019    Source:sciencedirect.com

A chiral phosphoric acid-catalyzed Friedel–Crafts alkylation of o-hydroxybenzyl alcohols with 3-alkylindoles has been established, which was used to construct a biologically important diarylindol-2-ylmethane scaffold in high yields and with good enantioselectivities (up to 99% yield, 90:10 er). Moreover, these novel compounds were subjected to tests to determine the in vitro cytotoxicity against carcinoma Hela cells. Nearly all of the tested compounds exhibited strong or moderate cytotoxicity to Hela cells with IC50 values ranging from 6.821 to 28.042 μg/mL.

We also recommend Trading Suppliers and Manufacturers of 3-BROMO-5-CHLORO-2-HYDROXYBENZYL ALCOHOL (cas 116795-47-2). Pls Click Website Link as below: cas 116795-47-2 suppliers

Prev:A simple synthesis of benzofurans by acid-catalyzed domino reaction of salicyl alcohols with N-tosylfurfurylamine
Next:Novel titanium(IV) complexes stabilized by 2-hydroxybenzyl alcohol derivatives as catalysts for UHMWPE production)