Inhibitors of sterol synthesis. Exogenous oleate reduces the inhibitory effect of 5α-Cholest-8(14)-en-3β-ol-15-one on the growth of CHO-K1 cells

Add time:07/12/2019    Source:sciencedirect.com

Summary5α-Cholest-8(14)-en-3β-ol-15-one, a hypocholesterolemic agent and a potent inhibitor of sterol biosynthesis, inhibited the growth of CHO-K1 cells incubated in medium containing fetal calf serum. The concentration of the oxysterol required to inhibit growth by 50% was 13 μM. Sodium oleate (82 μM) reduced the inhibitory effects of the sterol, and increased the concentration of the 15-ketosterol required to cause a 50% inhibition of growth to 25 μM. The ACAT inhibitor N′-(2,4-difluorophenyl)-N-[[4-(2,2-dimethylpropy)-phenyl]-methyl])-N-heptylurea (5 μM) abolished the effect of sodium oleate, and reduced the concentration of the 15-ketosterol required to inhibit growth by 50% to 5 μM.

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