Inhibitors of sterol synthesis. Effect of dietary 5α-cholest-8(14)-EN-3β-OL-15-one on acat activity of jejunal microsomes of the rat

Add time:07/14/2019    Source:sciencedirect.com

SummaryDietary administration (0.1% in a chow diet for 8 days) of 5α-cholest-8(14)-en-3β-ol-15-one, a potent inhibitor of sterol biosynthesis with marked hypocholesterolemic action, to rats caused a 77% reduction in the levels of acyl coenzyme A:cholesterol acyl transferase activity of jejunal microsomes relative to those observed in pair-fed control animals. No differences were observed in mean levels of cholesterol concentration in jejunal microsomes of experimental and pairfed control animals.

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