Experimental toxicity and metabolism of 1,2,6-Hexanetriol (cas 106-69-4)

Add time:08/19/2019    Source:sciencedirect.com

The toxicity of 1,2,6-hexanetriol was determined in rats, rabbits, and dogs. In rats the LD50 values are 16 ml/kg orally, 10 g/kg intraperitoneally, and 5.6 ml/kg intravenously. Inunctions of 2 ml/kg 30 times within 6 weeks produced no effect in rabbits. Fed in the diet of rats for 2 years, a 5% concentration reduced growth, increased relative kidney weight during the first year, and resulted in some cloudy swelling in liver and pancreas, but 1% was without deleterious effect. In the diet of dogs for 2 years, 1% was without effect.In rats, 79% of a large dose was found in the urine within 24 hours, apparently unchanged and unconjugated. The triol is not converted to glycogen and stored in the liver. Approximately 0.1% of the dose appears in rat urine as oxalic acid. The triol is considerably more potent a diuretic than glycerin.Hexanetriol is not appreciably toxic to rats, rabbits, and dogs when given in either single or repeated doses by various routes. It is essentially unmetabolized by rats.

We also recommend Trading Suppliers and Manufacturers of 1,2,6-Hexanetriol (cas 106-69-4). Pls Click Website Link as below: cas 106-69-4 suppliers

Prev:Catalyst studies on the ring opening of tetrahydrofuran–dimethanol to 1,2,6-Hexanetriol (cas 106-69-4)
Next:Experimental vapor pressures (from 1 Pa to 100 kPa) of six saturated Fatty Acid Methyl Esters (FAMEs): Methyl hexanoate (cas 106-70-7), methyl octanoate, methyl decanoate, methyl dodecanoate, methyl tetradecanoate and methyl hexadecanoate)